KMID : 1100720150350050531
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Annals of Laboratory Medicine 2015 Volume.35 No. 5 p.531 ~ p.534
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Emergence of Acinetobacter pittii Harboring New Delhi Metallo-¥â-Lactamase Genes in Daejeon, Korea
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Sung Ji-Youn
Koo Sun-Hoe Kim Se-Mi Kwon Gye-Cheol
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Abstract
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Carbapenemase production has been reported worldwide in gram-negative bacteria, including Acinetobacter species. We detected carbapenemase-producing Acinetobacter pittii in clinical isolates in Daejeon, Korea. Twenty-one ertapenem-resistant A. pittii isolates screened with a disk diffusion method were characterized by using the Epsilon test, four multiplex PCR assays, and a multilocus sequence typing (MLST) scheme. A total of 21 A. pittii isolates harbored the metallo-¥â-lactamase (MBL) gene blaIMP-1 or blaNDM-1. Nineteen isolates containing blaIMP-1 were resistant to imipenem and meropenem, but two isolates harboring blaNDM-1 were susceptible to them. The sequence types (STs) of the two New Delhi MBL (NDM-1)-producing A. pittii isolates were ST70 and ST207, which differed from the STs (ST63, ST119, ST396, and a novel ST) of the IMP-1-producing A. pittii. This is the first report on NDM-1-producing A. pittii isolates in Korea. Our results emphasize that the study of NDM-1-producing gram-negative bacteria should involve carbapenem-susceptible as well as carbapenem-resistant isolates.
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KEYWORD
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A. pittii, Carbapenem, Metallo-¥â-lactamase, NDM-1
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